Cholangiocarcinoma refers to malignant tumors originating from intra- and extra-hepatic bile ducts, including the hilar region to the lower end of the common bile duct. Cholangiocarcinoma has a high degree of malignancy and its incidence rate is increasing year by year in recent years. Then, what are the symptoms of cholangiocarcinoma in late stage? 1. Persistent dull pain in upper abdomen. Patients often have persistent abdominal pain, mostly in the upper abdomen, which is dull pain. 2.About half of the patients are accompanied by distension and fever in the middle and upper abdomen, but the degree is usually mild. 3.Loss of appetite, weight loss, nausea and vomiting, fatigue and emaciation. 4.Half of the patients may show itchy skin, which may appear together with weight loss and other symptoms. 5.Urine is dark yellow and strong tea color, and feces are gray. 6.Persistent obstructive jaundice: due to the difference of the site of onset, jaundice may be the main symptom of patients, but it may not appear. Jaundice can be found in 90%-98% of patients with extrahepatic cholangiocarcinoma, and most of them have persistent painless jaundice with gradual deepening. 7.Portal vein hypertension manifestations such as splenomegaly and ascites. 8.Patients have bleeding tendency, vomiting blood or black stool: biliary tract bleeding can occur when the tumor is ulcerated in advanced stage; when the ulceration occurs in the digestive tract, patients can show black stool, positive fecal occult blood test and anemia. 9. Liver enlargement, cirrhosis and pyloric obstruction symptoms. When the gallbladder duct is obstructed or the cancer metastasizes to the liver or neighboring organs, hard lumps can be detected in the upper abdomen of patients. If the cancer invades the duodenum, the patient may have the symptom of pyloric obstruction. At the time of consultation, it is mostly in advanced stage, and abdominal pain, weight loss, abdominal mass, and jaundice are less common.