Lupus, known as systemic lupus erythematosus, is an autoimmune disease in which pathogenic autoantibodies and immune complexes form and mediate organ and tissue damage. Most of the patients with SLE have an insidious onset and have complex and variable symptoms, with fever, rash, arthritis or arthralgia being the most common first symptoms. Initially, about 90% of patients have fever, usually low or moderate fever, and high fever can be seen in the acute stage. About 80% of patients have skin and mucous membrane lesions, typically butterfly-shaped erythema on the face, symmetrical rash on exposed areas or disc-shaped erythema. In addition, arthritis or arthralgia is also a common symptom, often presenting with symmetrical multi-joint pain and swelling, with finger, wrist and knee joints being the most common. It should be noted that in addition to the first symptoms mentioned above, some patients with SLE may also develop systemic manifestations such as fatigue, malaise, loss of appetite, emaciation, or impairment of urinary and hematological systems such as occult nephritis, leukopenia, mild anemia, thrombocytopenia, etc. as the first clinical manifestations. As the disease progresses, multiple system and organ damage manifestations such as pericardial effusion, nephritis syndrome, hepatosplenomegaly, headache and epilepsy may gradually appear. In some critically ill patients, hemolytic anemia, granulocyte deficiency, acute renal insufficiency, alveolar hemorrhage, severe pneumonia, acute abdomen and coma may also appear, which can be life-threatening if not treated in time. Therefore, since there are no obvious aura before the onset of SLE, and the early symptoms are complex and varied, lacking clinical specificity, women of childbearing age and those with a family history of lupus should consider the possibility of SLE if they develop the above symptoms and signs and seek timely treatment.