Lupus erythematosus often does not have obvious precursors before its onset and is easily overlooked. Lupus erythematosus is an autoimmune disease caused by the formation of a large number of pathogenic autoantibodies and immune complexes, which mediates the damage of multiple organs throughout the body, and the clinical symptoms are often diverse. The clinical symptoms are often diverse and insidious at the beginning of the disease, so the symptoms are often atypical in the early stage. Common initial symptoms can be divided into the following categories: 1. systemic symptoms: some patients can have various fever types, with low and moderate fever being common, as well as fatigue, malaise, decreased appetite, muscle pain, weight loss and other symptoms, which are often overlooked; 2. skin and mucosal symptoms: some patients have skin symptoms as the prodromal manifestation, such as skin erythema, papules, maculopapular rash and perineural Erythema, limb ischemia, facial torso rash, etc., among which the erythema with butterfly-shaped distribution on the nose, cheeks and cheeks is the most characteristic. There are also signs of mucosal damage, such as blisters and ulcers on the oral mucosa, hair loss and baldness, etc.; 3. Some patients may have morning stiffness, muscle weakness and muscle pain; 5. Kidney symptoms: Some patients have kidney disease, which is characterized by swelling of the lower limbs, darkening of urine and increasing foam in urine, and hematuria or proteinuria can be found in laboratory tests; 6. Therefore, for patients with lupus erythematosus, there are various prodromal symptoms, some of which are not obvious and atypical. When there are manifestations of multi-organ involvement in certain parts or the whole body, one should consider whether it is lupus erythematosus and go to the rheumatology and immunology department of the hospital for screening in time.