High alkaline phosphatase is not necessarily caused by a calcium deficiency. High alkaline phosphatase can occur in growing children and adolescents, in women during pregnancy, or in people who eat a fatty diet. This is a physiologic elevation that is normal and does not require treatment. In addition, diseases of the hepatobiliary system can also cause high alkaline phosphatase, mainly due to bile excretion disorders caused by biliary tract obstruction, such as primary liver cancer, cholelithiasis, bile duct cancer, pancreatic head cancer, peripancreatic cancer, and capillary biliary hepatitis. High alkaline phosphatase does, however, cause a drop in calcium ions, but this occurs not because of a calcium deficiency, but due to vitamin D deficiency or excessive bone destruction. Common disorders include rickets, achondroplasia, bone malignancies, bone metastases from malignant tumors, and hyperparathyroidism. Clinical reasons need to be further determined according to the symptoms, signs and relevant auxiliary examinations.