Alkaline phosphatase increase itself is the reaction of the human body state, not increase bring harm, but because of the pathological conditions lead to its increase, find the reason for treatment in order to bring down the elevated alkaline phosphatase. High alkaline phosphatase is physiological or pathological increase, as follows: 1, physiological increase is mostly seen in children’s bone development, as well as in the growth period of adolescents, as well as pregnant women, eating foods with high fat content can lead to physiological increase; 2, pathological increase is mainly seen in rickets, cartilage, bone malignant tumors and even bone metastatic tumors and other bone diseases, as well as extra-hepatic biliary atresia, hepatocellular carcinoma, Cirrhosis, capillary biliary hepatitis and other hepatobiliary diseases, hyperparathyroidism can also cause alkaline phosphatase elevation. Pathological elevation should be examined as soon as possible to determine whether it is of hepatobiliary, skeletal, or endocrine origin, and then the primary disease should be treated. Alkaline phosphatase is widely distributed in human tissues such as liver, bone, intestines, kidneys and placenta, etc. Alkaline phosphatase has many isoenzymes from liver, bone, placenta, tumor cells, small intestinal villous epithelium and fibroblasts, and specific alkaline phosphatases are mainly used for the diagnosis and differentiation of diseases of the skeletal and hepatobiliary systems.