Estrogen and progesterone sequential method, i.e., artificial cycle, that is, simulating the natural menstrual cycle, taking estrogen from the 5th day of the menstrual cycle for 21 days, adding progesterone for 10 days at the 11th day of the menstrual cycle, and stopping the medication for 3-7 days for the onset of menstruation, that is, an artificial cycle. Artificial cycle is by simulating the endocrine changes of the ovaries in the natural menstrual cycle, the sequential application of estrogen and progesterone, so that the endometrium undergoes corresponding changes and cyclic shedding occurs. Oral estrogens such as estradiol valerate and conjugated estrogens and progestins such as medroxyprogesterone acetate and dydrogesterone are used. Starting from the 5th day of menstruation or withdrawal bleeding, take 1.25mg of conjugated estrogen or 2mg of estradiol valerate once a day for 21 days, and from the 11th day of taking estrogen, add medroxyprogesterone acetate or dydroxyprogesterone, 10mg per day for 10 days, and then menstruation will occur in the 3-7 days of stopping, and then the next cycle will start on the 5th day of menstruation, and then 3 consecutive cycles will be the first course of treatment. The next cycle will start on the 5th day of menstruation. Artificial cycle is suitable for the treatment of irregular menstruation, dysmenorrhea, amenorrhea and other diseases, but it is best to use the drug under the guidance of gynecologists.