The soft tissue density nodule 1.3cm×1cm in the anterior superior mediastinum belongs to the description of mediastinal lesions in CT examination, and the specific treatment plan needs to be judged in conjunction with the etiology of the disease, and the main causes include enlarged lymph nodes, thymoma and metastatic tumors, etc. The specific treatment plan includes regular observation, surgical resection, and radiochemotherapy. 1. Enlarged lymph nodes: a large part of the corresponding conditions belong to reactive lymph node enlargement, without any symptoms, there is no need for special treatment, and only need to be regularly reviewed by CT. 2. Thymoma: it is a common tumor in the thymus area, and some of them will be accompanied by myasthenia gravis, and radical resection can be done directly after discovery. 3. Metastatic tumor: the corresponding part is the most common part of metastatic tumor, with the history of primary tumor, and the diagnosis of metastatic tumor can be controlled by radiotherapy, and generally can choose extracorporeal local radiotherapy, and the commonly used chemotherapeutic drugs include cisplatin. The soft tissue density nodule of 1.3cm×1cm in the anterior superior mediastinum, accompanied by myasthenia gravis or decline in physical condition, etc., need to consult a doctor in time for observation, and carry out standardization under the guidance of the clinician after diagnosis of the disease.