No specific medications exist for the treatment of persistent chronic eczema. Drugs that can be used to treat persistent chronic eczema include glucocorticoid ointment, calcium-modulated phosphatase inhibitor ointment, and oral antihistamine drugs. 1. Glucocorticoid ointment: such as dexamethasone cream, hydrocortisone butyrate cream, is an adrenocorticotropic hormone class of drugs, anti-inflammatory, anti-allergic, anti-itching effect, can alleviate the symptoms of eczema, but the long-term application of the skin can be atrophic, dependence. 2. Calcium-modulated phosphatase inhibitor ointment: such as tacrolimus ointment, pimecrolimus cream, etc. can improve the skin lesions through a variety of anti-inflammatory pathways. Long-term use is not prone to skin atrophy, hirsutism and other side effects, suitable for the face and neck, perineum, elbow and popliteal fossa and other parts. 3. Antihistamine drugs: such as loratadine, cetirizine can relieve itching caused by eczema. Taking this product can produce side effects of drowsiness, fatigue. Do not drive or work at heights while taking this product to avoid danger. Patients with persistent chronic eczema should use medication under the guidance of a dermatologist interview, pay attention to the adverse effects of the medication as well as contraindications, do not self-medicate, do not believe in special-effect drugs.