Positive core antibodies to the hepatitis B virus and negative core antibodies are generally not serious. Hepatitis B virus core antibody positive and other negative, this condition generally indicates previous infection with the hepatitis B virus, because the core antibody is a permanent marker, once infected permanent presence. Hepatitis B core antibody positivity needs to be analyzed together with hepatitis B surface antigen and hepatitis B E antigen to have clinical significance, and alone can only indicate previous infection. Clinically, hepatitis B virus infection does not necessarily have symptoms, and even some patients with triple positive or triple positive do not have clinical symptoms. We mainly rely on liver function tests to determine the severity. If liver function is abnormal, corresponding symptoms such as jaundice, indigestion, endocrine disorders and even edema will appear. If the liver function is normal, usually only a review is needed.