Earth kinase can not be taken twice a day, the effect of the drug will be reduced, and can not achieve the therapeutic effect. Earth kinase is a special substance extracted from the body of earthworms, with an anti-thrombotic effect, able to inhibit platelet aggregation, clinically used in the treatment of ischemic cardiovascular and cerebrovascular diseases, such as cerebral infarction, coronary heart disease and so on. Earth kinase belongs to the prescription drugs, you need to take the drug three times a day, taking the drug twice a day may lead to a decrease in the concentration of the drug, can not effectively inhibit the aggregation of platelets, the effect of the drug will be significantly reduced, to be taken three times a day in accordance with the provisions of the instructions of the drug. Adverse reactions of earth kinase include stomach upset, nausea, diarrhea, rash, itchy skin, etc. It is contraindicated in patients who are allergic to the components of the drug and in patients with active bleeding. When taking earthworm kinase orally, it is important to follow the doctor’s instructions, specify the dosage and frequency of the drug, to ensure that the drug can be formally exerted.