Cranial defect is a very important piece of human skeletal tissue, which plays the role of supporting and protecting the brain. If cranial defect occurs, the brain loses its protective barrier and the operation of all life activities in the skull will be affected. Skull defect should be alerted, the defective part will not easily grow up by itself, and the defective part may collapse and deform over time, which will seriously damage the appearance and image, and also affect the neurological function, leading to a series of skull defect syndrome, which has great impact on the life and work of patients. In clinical practice, if the skull defect area is more than 3cm in diameter, it is recommended to go to hospital for skull repair surgery in time, so as to reshape the closed cranial cavity environment and allow all neurological functions and life activities to function normally. However, the choice of repair material is very important in skull repair surgery, and good material can greatly improve the success rate of the surgery. Titanium mesh material is now widely used in many hospitals, which is much more advanced than the early repair materials, but there are some shortcomings and defects, such as the chance of infection and rejection after surgery, the sensitivity of the surgical site to the external hot and cold environment, easy deformation by external forces, and even the risk of material exposure, etc. Titanium mesh materials are problematic, a new type of polyetheretherketone peek material has emerged, polyetheretherketone peek material is what material? This is a very excellent special polymer material, its various properties are compatible with the autologous cranial bone, overcoming the shortcomings of the titanium mesh material, the clinical surgical results are very good. We have successfully applied peek material to carry out surgery, and the team has continuously carried out technical improvement and upgrade and material optimization design, and also introduced the concept of aesthetic plastic surgery in the surgery, which really achieves the organic unity of beautiful appearance, perfect function and structural integrity after surgery.