The causes of menstrual failure are complex, and systemic treatment should be carried out, including active treatment of systemic diseases, improving the body’s physical fitness, supplying adequate nutrition, and maintaining a standard weight. Exercise amenorrhea should be reduced appropriately. Amenorrhea due to stress and mental factors should be treated with patient psychotherapy to eliminate mental tension and anxiety. Amenorrhea caused by tumors and polycystic ovary syndrome should be treated for the cause. After identifying the lesion link and the cause, the corresponding hormone therapy should be given to supplement the hormone deficiency in the body or to antagonize its excess for therapeutic purposes. The purpose of hormone supplementation therapy is to maintain female health and reproductive health, including the cardiovascular system, bone and bone metabolism, and the nervous system, and to promote and maintain secondary sexual characteristics and menstruation. The treatments are estrogen supplementation therapy for those without a uterus; estrogen and progestin artificial cycle therapy for those with a uterus; progestin therapy for patients with a certain level of endogenous estrogen in the body who are once amenorrheic; ovulation promotion for patients with fertility requirements; adrenocorticotropic hormone for amenorrhea due to congenital adrenocortical hormone hyperplasia; thyroxine, such as thyroxine tablets, for amenorrhea due to hypothyroidism; bromocriptine, a dopamine agonist, for patients with abnormal pituitary function resulting in increased lactogenic amenorrhea.