Chemotherapy has long been considered a double-edged sword for patients with malignant tumors, as it can kill cancer cells, but it also invisibly damages normal cells, so that patients have to endure huge side effects such as hair loss and vomiting. Now there is a new treatment method called “hourly chemotherapy” that will change this dilemma. Different drug toxicity at different times The 24-hour alternation of light and darkness is the main environmental signal that generates circadian rhythms, and the physiological activities of the human body show regular changes with the 24-hour alternation of day and night, with peaks and valleys occurring at predetermined times. This change affects the metabolism of drugs, experts said, and this change gave inspiration to experts who injected more than 30 kinds of anticancer drugs into experimental rats and mice at different times, respectively, and found that different times can significantly affect the degree of toxicity and anticancer activity of the drugs. For all of these drugs, the change in toxicity varied from two to eight times for the same dose, depending on the time-adjusted dosing regimen. When experts will be the maximum tolerated dose of a certain anticancer drug were given in the light after 3, 7, 11, 15, 19, 23 hours after breast cancer mice, the results found that the light 7 hours to give the drug tumor shrinkage rate is the highest, up to 60%, the survival rate of 100%, while the light after 3 hours to give the drug tumor shrinkage rate of 0, mortality rate of 100%. The hourly chemotherapy closely follow the human life rhythm The hourly chemotherapy is the use of the above research results, according to the human body’s 24-hour biological rhythms that is “biological clock” changes in the selection of chemotherapy drug toxicity will be the smallest time of the chemotherapy drugs into the body of the treatment method, so as to increase the dose of chemotherapy drugs and its effectiveness doubled or even increased by a factor of several. Director Tian compared it to the time chemotherapy, that is, when the cancer cells are active and the normal cells are resting and “napping”, the drugs are used. At present, experts have researched the best time to use 5-FU drugs, platinum drugs, vincristine and other anti-cancer drugs. Some of them are suitable to be given in the morning, and some of them are suitable to be given in the afternoon or evening. Hourly chemotherapy has been tried abroad, and recently, a few big hospitals in Nanjing have started to use it among patients. The hourly chemotherapy can be realized with the help of a square drug pump, which is a special drug pump that can strictly control the drug delivery time and accurately apply the hourly chemotherapy program to the clinic, which is completely different from the traditional concept of constant speed drip. Director Tian pointed out that clinical studies have also proved that the use of hourly chemotherapy, the patient’s reaction is lighter, “before to use four antiemetic drugs, now only need to use two will be enough, before the chemotherapy, to use a large dose of drugs to increase the white blood cells, and now also use less. At present, hourly chemotherapy is used more in the treatment of stomach and intestinal tumors.”