The most obvious difference between irritable bowel syndrome and enterocolitis is the presence or absence of organic damage to the intestinal tract, and there are also differences in the clinical manifestations and etiology of the two. Irritable bowel syndrome is a functional intestinal disease, the pathogenesis is not clear, and it is related to psychosomatic disorders and abnormal gastrointestinal dynamics. There is no organic lesion of the intestinal tract, and the clinical manifestations may include abdominal pain, abdominal distension, diarrhea or constipation; abdominal pain is related to defecation, and there is usually no mucus-pus-blood stool. Enteritis is a non-specific inflammation of the intestinal tract, related to infection, autoimmunity, genetics, etc. It can be categorized into infectious enteritis, ulcerative colitis, Crohn’s disease and so on. There are organic changes in the intestinal tract, and the clinical manifestations may include abdominal pain, abdominal distension, diarrhea, accompanied by mucopurulent and bloody stools. Patients with both irritable bowel syndrome and enteritis should go to the hospital in time and standardize their treatment under the guidance of their doctors.