A fleshy bump in the armpit is considered to be a condition such as folliculitis, sebaceous cyst, or soft fibroma. It needs to be treated according to the specific situation, usually including medication, physical therapy and surgical treatment. 1. Folliculitis: If the hair follicles in the armpit are infected by bacteria, folliculitis will be formed, the main symptom of folliculitis is redness, swelling, itching and pain, the treatment of folliculitis should control the inflammation, commonly used oral medication amoxicillin, cefuroxime, topical medication mupirocin ointment, clindamycin ointment and so on. 2. Sebaceous cysts: mostly due to sebaceous gland ducts blocked leading to sebum retention to form cystic structures, which is manifested as a subcutaneous swelling. Usually there are no conscious symptoms, and can be treated with elective surgical excision. If secondary bacterial infection, accompanied by redness, swelling, heat and pain, it is necessary to first anti-infection treatment, such as oral amoxicillin. 3. Soft fibroma: If the bumps exist in the form of skin tumescence on the outside of the skin, it is considered soft fibroma, which is a kind of benign tumor, and can be removed by laser and other physical methods for treatment. There may be other reasons for the above situation, it is recommended to consult a dermatologist, under the guidance of the doctor targeted treatment. The above medications should be used in accordance with medical advice.