The development of colorectal cancer is related to many factors, such as dietary habits, heredity, and inflammation of the colon, etc. 1, dietary factors: such as high fat and low fiber diet; animal protein, high content of nitrosamines and their derivatives in food; alcohol intake; fried food; vitamin A, C, E and selenium deficiency of trace elements, etc. Dietary factors are considered to be extremely important in the development of colorectal cancer. In the United States, this is also confirmed by the declining trend of colorectal cancer incidence due to the advocacy of dietary changes since the 1950s. In contrast, with the increasing improvement of people’s living standard in China, the dietary habits of Chinese people have also undergone great changes, with high-fat, high-protein and high-calorie foods increasing in the menu. This is also the reason for the increasing incidence of colorectal cancer in China. 2.Some benign lesions of the colon: such as chronic ulcerative colitis, colonic adenoma, familial colonic adenomatosis, schistosomiasis, colonic polyps, etc. The risk of colon cancer in people with chronic ulcerative colitis for more than 10 years is several times higher than in the general population, because the repeated inflammation in the intestine is a chronic stimulation of the intestinal mucosal cells, and this stimulation over time can lead to uncontrolled growth of mucosal cells and malignant changes. The relative risk of colorectal cancer is 22 times higher than that of those without polyps, because although polyps themselves are benign, they may become malignant. Genetic factors: It is estimated that genetic factors may play an important role in about 20% of colorectal cancer patients, such as familial adenomatous polyposis, hereditary non-polyposis colorectal cancer is the most common hereditary colorectal cancer. Studies have found that the risk of colorectal cancer is 2-4 times higher for children of colorectal cancer patients than for the general population, and about 10%-15% of colorectal cancer occurs in people with a history of colorectal cancer in first-degree relatives. 4.Occupational factors and health habits: lack of physical activity can increase the risk of colon cancer. However, it is generally not considered that colorectal cancer is an occupational disease.