You should not take cold medicine after drinking alcohol. Drinking alcohol can cause certain damage to liver and kidney functions, and drugs are metabolized through the liver, and alcohol is also metabolized through the liver, which can aggravate liver damage and also lead to damage to the stomach mucosa, nausea, vomiting or stomach discomfort. Disulfiram-like reactions can easily occur if you take drugs after drinking. Disulfiram reaction means that if you drink alcohol after taking the drug, you will experience facial flushing, increased blood pressure, increased heart rate, conjunctival or mucosal congestion, blurred vision, violent pulsation of the blood vessels in the head and neck, or pulsating headache, dizziness, nausea, and vomiting. Some people are more serious and may experience chest pain or even myocardial infarction, which is very dangerous. Some people may also experience acute respiratory distress, acute liver injury, or even acute heart failure, all of which can lead to death.