Ibuprofen is an anti-inflammatory and analgesic drug commonly used in clinical practice for pain caused by bone and joint diseases, or for fever and headache caused by cold and flu. Some patients may experience gastrointestinal symptoms after taking ibuprofen orally, such as upper abdominal discomfort, acid reflux and heartburn, when ibuprofen may cause irritation to the gastric mucosa. Drinking alcohol can also stimulate the gastric mucosa, and taking ibuprofen orally after drinking alcohol can aggravate the side effects of ibuprofen. In addition, ibuprofen may affect the metabolism of alcohol, which may cause some adverse reactions, such as disulfiram-like reactions or gastrointestinal bleeding in serious cases, so you should not take ibuprofen after drinking alcohol.