Clinically, high myoglobin may be damaged cardiomyocytes or skeletal muscle cells, mainly because myoglobin exists in the cytoplasm of these two cells, and if it is damaged and the cell membrane integrity is destroyed, myoglobin is released into the blood and the measurement value is high. Infection and trauma may cause damage to cardiomyocytes and skeletal muscle cells for the following reasons: 1. Heart disease: due to various infections, hypoxia, etc. When the normal metabolism of cardiomyocytes is affected by various reasons such as infection and hypoxia, the integrity of the cell membrane is damaged, myoglobin is released into the blood, and the measurement value is high. It can be used to monitor acute infarction and other heart diseases, and is also a common clinical reference indicator; 2, skeletal muscle injury: such as crush injury, violent trauma, etc., so that skeletal muscle tissue pressure, ischemia, etc., resulting in a series of reactions such as cell membrane destruction, cell lysis, etc., when the blood is perfused again so that myoglobin and other cell contents into the blood, and in serious cases, may lead to acute kidney injury. In addition, drug factors, carbon monoxide poisoning, rhabdomyolysis, endocrine metabolic disorders and other factors may make the myoglobin value high, the specific should be combined with the patient’s symptoms, the original disease and other comprehensive consideration for diagnosis and treatment.