Hand-foot syndrome is an adverse reaction of the skin that occurs in cancer patients during antitumor therapy. The hand-foot syndrome is clinically categorized into three levels, depending on the degree of the adverse reaction. Grade I hand-foot syndrome refers to numbness, pins and needles sensation, erythema and flaking of the skin of the patient’s hands and feet, which will not affect the patient’s daily life. Grade II refers to numbness, pins and needles, erythema, flaking, and swelling in the hands and feet of the patient, which can affect the patient’s daily life. Grade III means that on top of the grade II lesions, the patient develops blisters, ulcers, and severe pain, which can have a serious impact on the patient’s daily life.