Hand-foot syndrome is a form of skin toxicity caused by chemotherapeutic agents. Typical clinical presentation of hand-foot syndrome is a progressively worsening skin lesion commonly found on the palms of the hands-sole of the feet, with the hands being more susceptible to involvement than the feet. The first symptoms are itching of the skin of the palms and soles of the feet, congestion of the palms, fingertips and soles of the feet; followed by a painful sensation at the end of the fingers/toes, erythema and tension in the skin of the hands/feet, dullness of sensation, numbness, roughness of the skin, chapped skin, and, in a few patients, a cut-throat-like skin breakdown of the skin of the fingers, with blisters, desquamation, peeling, exudate, and even ulceration, and may be followed by infection. Chemotherapy drugs that cause hand-foot syndrome include capecitabine and doxorubicin. Treatment and prevention of hand-foot syndrome: 1. Avoid contact with hot objects, avoid skin trauma and prolonged direct sunlight exposure (sunscreen can be applied when going out), wear loose shoes, socks and gloves, and avoid heavy physical activities. 2. Local topical surface anesthetics or Benadryl cream can reduce pain and discomfort. If local blisters or ulcers appear, antibiotics can be applied to prevent infection.3. Vitamin B6 and celecoxib have certain preventive and therapeutic effects on hand-foot syndrome.4. Mild hand-foot syndrome does not affect chemotherapy, and there are no serious complications, so there is no need to worry too much. If grade 2-3 symptoms occur, consider adjusting the dosage or appropriately extending the dosing interval, and stop chemotherapy if necessary.