Amoxicillin is an antibiotic in the penicillin class and is one of the common antibiotics that can be used during childhood. However, because of the high chance of allergy to this class of drugs, it is contraindicated for individuals with a history of penicillin allergy. Individuals with a family history of penicillin allergy need to apply with caution or are not recommended for use. Some people have a history of allergy to cephalosporins and may have cross-allergic reactions with penicillins, which also need to be applied with caution when using them. And once applied, the patient needs to be closely observed for any discomfort that may occur during treatment. For example, if there is a sudden and obvious manifestation of clear watery nose, sneezing, difficulty in breathing, skin rash, hives, irritability, palpitations, etc., it is necessary to consider the possibility of allergy, discontinue the drug in time, and promptly ask the doctor for consultation and treatment.