There are many reasons for nipple pain in a 50-year-old woman, which are analyzed as follows: 1, nipple trauma, such as nipple being squeezed or scratched resulting in nipple pain. You can wear loose underwear, if the nipple is swollen and congested, you can apply hot compresses, massage or physiotherapy, and if necessary, treat with Yunnan Baiyao aerosol, if there is a wound you can apply erythromycin ointment.2. Mammary hyperplasia, endocrine disorders during menopause can lead to breast swelling and pain, as well as nipple swelling, pain, and erection. You need to go to the regular hospital for endocrine regulation, and take traditional Chinese medicine to regulate it if necessary.3. Mastitis, if the nipple is ruptured, bacterial retrograde infection will lead to mastitis, and there will be pain in the nipple, nipple overflow, and breast swelling and pain, you can take anti-inflammatory drugs to reduce inflammation, and apply erythromycin ointment on the nipple.4. Breast Cancer, the cancer invades the nerves and will have the manifestation of pain in the nipple, and the nipple retracts, and so on.