The treatment of advanced pancreatic cancer is mainly aimed at pain relief. Although there are many methods for cancer pain relief nowadays, especially the constant updating of pain relief drugs has improved the pain relief effect of advanced tumors in different ways. However, there is still a lack of truly effective and lasting pain relief methods. The pain relief effect of radiotherapy on pancreatic cancer has been confirmed, because pancreatic cancer is located in the retroperitoneum and surrounded by several radiation-sensitive organs including gastrointestinal, spinal cord and kidney. In the past, conventional external irradiation was difficult to locate precisely and the radiation reaction was large, which was difficult to be tolerated by most patients and it was difficult to give sufficient effective dose of irradiation. With the clinical application of three-dimensional conformal and intensity-modulated radiotherapy, the side effects of radiation therapy for pancreatic cancer have been significantly reduced and the treatment effect has been improved accordingly. The advantages of three-dimensional conformal and intensity-modulated radiotherapy techniques are: precise positioning, so that the target area is irradiated at a high dose and the normal tissues around the target area are better protected, thus allowing relatively high irradiation doses to be given to the tumor without increasing the damage to normal tissues, achieving a therapeutic gain from the technology. The results reported in the literature and the cases we treated showed that 3D conformal radiotherapy had better recent results. Pain relief was evident in most patients after treatment, and a reduction in early jaundice was obtained. Compared with conventional irradiation, 3D conformal radiotherapy is significantly better than conventional radiotherapy in terms of pain relief rate, tumor regression rate and survival rate because of the precise positioning, the lesion area can be irradiated with uniform higher dose, and the normal tissues are protected to a certain extent; moreover, the gastrointestinal reaction is also significantly lighter, especially for patients with significant pain, which can play a good pain relief effect.