Chest tightness, also known as “breathlessness”, is a subjective sensation that sometimes manifests itself as labored breathing or lack of breath after activity. This is a subjective feeling, sometimes it may also manifest itself as a struggle to breathe or a lack of breath after activity. Chest tightness can be a functional manifestation of impaired organ function in the body, or it can be one of the earliest symptoms of certain diseases occurring in the human body. The cause of chest tightness is different for people of different ages, the treatment is different, and the consequences are also different. Mr. Wang, who is over 40 years old, has been experiencing chest tightness and precordial discomfort repeatedly in the past six months, with each episode lasting 10-30 minutes and accompanied by a feeling of breathlessness, which is more intense when entering the subway and newly renovated offices; however, there is no obvious cough or wheezing symptoms, and it can be relieved by itself when staying outdoors. Mr. Wang had no past history of chronic bronchitis or smoking, and also occasionally participated in some physical activities, such as swimming and table tennis. He visited several hospitals in the city and had many tests, none of which revealed any significant abnormalities, and he received various diagnoses: coronary heart disease, myocardial ischemia, neurological disorders, etc. According to the diagnosis of the disease also received the corresponding drug treatment, but the symptoms of chest tightness has not been significantly relieved, for which Mr. Wang has been troubled. Many people may wonder, there is no wheezing and no cough, only chest tightness, can it be bronchial asthma? The answer is yes. Respiratory medicine experts remind: wheezing is not the only manifestation of asthma! The clinical manifestations of atypical bronchial asthma are diverse and patients are often misdiagnosed as bronchitis, pneumonia, upper respiratory tract infection, coronary heart disease, angina pectoris, neurosis and other diseases. The possibility of atypical bronchial asthma should be thought of if the following symptoms occur: 1. recurrent nighttime cough or morning cough; 2. chest tightness, cough or increased cough after activity; 3. recurrent cold that does not heal and lasts for more than ten days; 4. prolonged cough with itchy throat that occurs after a cold; 5. frequent cold with runny nose, nasal congestion, sneezing or itchy skin; 6. recurrent pneumonia with seasonal exchange-related; 7, children with restless sleep at night, frequent nose and eye rubbing during the day, and a family history of similar symptoms. The more common atypical bronchial asthma currently includes two categories: cough variant asthma and chest tightness variant asthma, of which the latter is typically characterized by the absence of wheezing and dyspnea symptoms of traditional bronchial asthma patients and the absence of recurrent coughing, but they have airway hyperresponsiveness and reversible airflow limitation, and Mr. Wang’s condition should fall into this category. In conclusion, prolonged chest tightness must be taken seriously enough by patients so as not to delay necessary treatment. Chest X-ray, ECG, blood biochemistry and pulmonary function tests should be performed in the relevant departments of the hospital so that clinicians can further confirm the diagnosis, and only by treating it correctly can we get timely diagnosis and reasonable treatment, thus improving the quality of life.