If a psychiatric patient refuses to take medication, the patient’s current situation should be evaluated. If the patient is currently at significant risk of impulsivity or self-injury or self-harm, and a great danger exists for society or for himself or herself, he or she can take the medication covertly at this time, such as hiding the medication for treatment in the patient’s meal or using an aqueous agent to mix it into the patient’s water, or he or she can be treated with an injection or long-acting injection, once a month. Because the treatment of psychosis must be standardized with the correct medication, if this is not done, it is difficult for the patient’s symptoms to improve effectively. If the patient is extremely ill and refuses to take medication, physical therapy, such as twitch-free electroconvulsive therapy, can be used at this time. Twitchless electroconvulsive therapy is very effective for psychotic patients with self-injurious or self-injurious behavior or apparently aggressive impulsive behavior. After MECT is administered to control the patient’s symptoms, many patients can regain self-awareness and can voluntarily cooperate with medication treatment. Therefore, if a psychotic patient refuses to take medication, it is important to assess the patient’s status and choose a reasonable way to respond according to the status.