After the performance of cranial defect, there is localized swelling, pain at the edge of the defect, intolerable cerebral pulsation, and the brain tissue of the defect site is plunged into the intracranial area when the patient is standing upright; when the patient is lying down, the brain tissue of the defect site is puffed outward. It seriously affects the patient’s physical health, such as severe headache, dizziness, easy fatigue, irritability, memory loss, depression, and decreased tolerance to vibration and sound. Some patients’ symptoms worsen with changes in body position. The causes of skull defects can be seen in open craniocerebral injury, especially after debridement of firearms injury, the skull itself is fractured, fragmented, the wound is a bacterial open wound, easy to be infected, and the fracture can not be reset; closed craniocerebral injury to remove hematoma, thwarted inactivation of brain tissue is still high intracranial pressure, and decompression of bone flap; osteoma and other cranial lesions after resection and so on, which left a cranial bone defects. Cranial bone repair should be performed as early as possible after cranial bone defects. At present, PEEK material is the ideal material for cranial bone repair because PEEK material has very good histocompatibility and basically does not produce rejection reaction, PEEK material has good ray transmittance, which does not affect all kinds of postoperative medical examination. In addition, PEEK material in the elasticity, strength, thermal insulation, stability and other aspects of the performance of the human skull are comparable to the human skull, is a very ideal cranial bone repair material.