Hypersplenism is usually caused by congestive enlargement of the spleen and spleen fibrosis due to increased portal pressure in cirrhosis. The incidence of hypersplenism is very high among patients with liver disease. If the hypersplenism is mild, it can be treated without treatment, and the main focus is on regulating the primary disease. Correction of hypersplenism can increase the number of blood cells, which can bring the disease under control. There are also some patients with hepatitis B or C along with hypersplenism in cirrhosis who cannot initiate standard antiviral therapy due to blood cell reduction or cannot discontinue antiviral therapy during treatment, making some patients with cirrhosis induce infection, bleeding and anemia due to the reduction of blood cells, leading to various dangerous situations, which require timely symptomatic treatment. Increased intrahepatic blood pressure in cirrhosis leads to spleen congestion and enlargement, and high circulatory reflux power in turn aggravates portal hypertension. Such a vicious circle leads to hypersplenism. Therefore, when treating hypersplenism, it is important to correct the blood cells in a timely manner to avoid producing changes in blood cells and various blood disorders. If physical conditions allow, splenectomy can also be considered to cure hypersplenism radically.