Chronic colitis with mucus and blood in stools can be treated with general treatment and medication. 1. General treatment: pay attention to keep the diet of light, easy to digest, diarrhea is serious need to bed rest. 2. Medication: For chronic non-specific colitis, mesalazine should be used to inhibit the inflammatory reaction of the intestinal wall, and prednisone can also be used to control the progress of the disease; for chronic infectious colitis, if accompanied by bacterial infections, doxycycline and other antibiotics should be used; for colitis accompanied by viral infections, antiviral medications, such as acyclovir, need to be considered. 3. Surgery: Surgical resection can be performed if there is bowel perforation or if medication is ineffective. If you are diagnosed with chronic colitis and have mucus with blood in the stool, it is recommended that you go to the hospital for treatment under the guidance of your doctor.