When adenocarcinoma of small intestine has two lymph nodes metastasis in stage III, it is mainly resected by surgery. When the patient has lymphatic metastasis, it already belongs to the middle and advanced stage of the disease. Surgical resection is mainly carried out to completely remove the whole section of intestines where the tumor is located, the corresponding mesentery and the lymph nodes belonging to the tumor, and the corresponding chemotherapy is carried out after the operation, such as the selection of irinotecan, oxaliplatin, raltitrexed and other medicines, which can effectively prevent the cancer cells from continuing to proliferate and grow, prolong the life cycle, alleviate the symptoms, and improve the quality of survival. Quality. Patients with stage III adenocarcinoma of small intestine with lymph node metastasis should seek medical treatment in time, and need to actively cooperate with treatment, such as taking medicine, surgical resection, and post-treatment, under the evaluation and guidance of professional doctors in regular hospitals. During the treatment period, patients should pay attention to the nutritional and light diet, avoid spicy and stimulating food, and have regular outpatient rechecks.