Creatinine 116μmol/L in 45 years old male is generally not serious if it is due to physiological factors such as muscular athletes, etc. If it is due to acute renal failure, it can be returned to normal after removing the cause of the disease, and it is also not serious; if it is due to chronic renal failure, it is relatively more serious, because the disease may slowly progress to uremia. Creatinine level in men is usually between 53~106μmol/L, but due to different methods of testing in each hospital, the normal range as well as the test results vary. High creatinine may be a physiologic change caused by recent high meat consumption, muscular athletes, and heavy exercise, etc. It is generally not serious and can be reviewed regularly. If it is an acute elevation due to diarrhea, infection, gastrointestinal bleeding, urinary tract obstruction, etc., the creatinine can usually return to normal after the cause is removed, so it is not considered serious either. Chronic elevation due to nephritis, hypertensive nephropathy, diabetic nephropathy, etc. can be relatively serious, because it is generally incurable and can slowly progress to uremia. Patients with elevated creatinine are advised to consult regular hospitals in time and standardize the treatment under the guidance of physicians.