Drugs that lower blood pressure quickly without causing a rapid heartbeat include metoprolol and hydrochlorothiazide. 1. Metoprolol belongs to β-receptor antagonist, which can inhibit myocardial contractility and slow down the heart rate after use, thus exerting the effect of lowering blood pressure. It is mainly used in the treatment of hypertension, angina pectoris, myocardial infarction, arrhythmia and other diseases. The drug can reach the peak drug concentration in about 1~2 hours after use, thus exerting its medicinal effect. However, discomfort such as bradycardia, dizziness and headache may occur. Liver and kidney functions need to be monitored in the course of taking the drug, while those who are allergic to the components of the drug are prohibited, and pregnant and lactating women need to use the drug under the guidance of a doctor. 2. Hydrochlorothiazide belongs to diuretics, after using it, it can reduce the extracellular volume and lower the resistance of peripheral blood vessels, so as to play the role of lowering blood pressure. It is mainly used in the treatment of hypertension, nephrogenic uremia, water-sodium retention and other diseases. Usually, the drug can be absorbed rapidly after oral administration and reaches the peak concentration of the drug in about 2 hours, thus exerting the effect of lowering blood pressure. However, it may cause skin rash, dry mouth, nausea and other discomforts. The drug is prohibited for those who are allergic to the components of the drug, and blood pressure needs to be monitored in the process of taking the drug, and pregnant and lactating women need to use the drug under the supervision of a doctor. All of the above medications should be used under the guidance of a doctor, avoid self-medication to avoid adverse consequences.