Heartburn in the middle of the night is mostly caused by digestive disorders and insufficient gastric power, which can be improved by taking drugs to inhibit gastric acid secretion, gastric mucous membrane protection drugs, and drugs to promote gastric power. 1. Inhibit gastric acid secretion drugs: you can take proton pump inhibitors, such as omeprazole, lansoprazole, pantoprazole and other drugs, can inhibit the secretion of gastric acid, improve the symptoms of acid reflux heartburn. 2. Gastric mucosal protectants: commonly used drugs are colloidal bismuth pectin, aluminum magnesium sulfate, bismuth potassium citrate, etc., which can protect the gastric mucosa from the destruction of gastric acid. 3. Promote gastric power drugs: such as domperidone, mosapride, etc., can promote gastrointestinal peristalsis, relieve the symptoms of acid heartburn. These drugs have different degrees of side effects, such as nausea and vomiting, constipation, allergies, drowsiness, dizziness, etc. When taking these drugs, you must strictly follow the doctor’s instructions under the guidance of the doctor, do not self-medicate.