The main reason for the high creatinine level is the cause of the high creatinine level: 1. If the acute nephritis causes a transient creatinine level, it is not necessary to take medication at this time, as most patients can improve on their own. 2. If the creatinine is high due to infection, you can choose cephalosporins or penicillins for anti-infection treatment, because cephalosporins and penicillins have less impact on kidney function and are not nephrotoxic. 4, if the creatinine is high due to chronic renal failure, you can use creatinine-lowering drugs at this time, such as clinically used uricosuria, rhubarb sodium bicarbonate tablets and activated charcoal, all of which are can eat, can achieve the purpose of lowering creatinine.