4, some trace elements abnormalities, such as copper, aluminum, magnesium, selenium, zinc metabolism abnormalities; 5, renal bone disease: manifested as bone and joint pain, mostly systemic, to the lower body weight-bearing bone, proximal muscle weakness, skeletal dissolution deformity, can also cause short stature; 6, metabolic acidosis: can appear deep and long breathing, loss of appetite, nausea and vomiting, weakness, headache, even coma, The symptoms of metabolic acidosis include deep and long breathing, loss of appetite, nausea and vomiting, weakness, headache, restlessness, and even coma; 7.