In conjunction with the instructions, if you take Metformin once a day, it is recommended that it is best taken with a meal when eating dinner to reduce the incidence of adverse reactions. Metformin is indicated for patients with type 2 diabetes who do not respond well to diet or exercise therapy alone, either alone or in combination with a sulfonylurea or insulin. If metformin is to be taken once a day, it is best taken with a meal when eating dinner to minimize its gastrointestinal adverse effects. Adverse effects of metformin include nausea, vomiting, diarrhea, constipation, dyspepsia, dizziness, headache, flu-like symptoms, muscle pain, chest discomfort, etc. It is contraindicated for those who are allergic to the product, those with hepatic or renal insufficiency, heart failure, acute myocardial infarction, and ketoacidosis. For the application of metformin, please take medication under the guidance of a physician, and should not be used blindly.