Hand, foot and mouth disease is caused by enterovirus infections, and the causes include two main aspects, namely, pathogenic contact and the patient’s own body immunity deviation. 1. Pathogen contact: This disease is an infectious disease, and in daily life, contact with the disease through the digestive system, respiratory system, etc., will lead to pathogen infection. 2. Immunity deviation: this disease is common in infants and young children, mainly because of the incomplete development of the immune system and immunity deviation, which will lead to massive propagation of the pathogen in the body after contact with the pathogen, and cause viral infections related to the disease. After the emergence of hand, foot and mouth disease, most of the need for symptomatic treatment, the body obvious fever need to apply antipyretic drugs (ibuprofen, etc.); systemic multi-system symptoms, the need for the application of gammaglobulin and so on. HFMD requires prompt medical attention and standardized care under the guidance of a clinician to avoid delays.