With the rapid development of economy and medical science, human lifestyle has been greatly improved and the desire to delay aging has become stronger and stronger. Although there are numerous studies on the mechanism of aging and anti-aging so far, which are not yet unified, a large number of previous studies have found that moderate exercise has a certain delaying effect on aging and is related to various aging doctrines. By reviewing a large amount of relevant domestic and international literature, this chapter focuses on the progress of anti-aging research on exercise and proposes a detailed scientific exercise program for anti-aging. Exercise is any physical activity that enhances or maintains physical health and overall health. It promotes the function of all organ systems in the body through muscle activity, resulting in enhanced physical fitness, improved immune function and faster metabolism, while relieving stress, playing an active role in the prevention of heart, lung and bone system diseases, and improving the body’s adaptability to the external environment. According to the National Heart, Lung, and Blood Institute (NHLBI), exercise is generally divided into three types based on its overall impact on the body: aerobic, anaerobic, and stretching exercises. Aerobic exercise: also known as endurance exercise, characterized by the ability to ensure an adequate supply of oxygen during exercise. Therefore, the intensity of exercise is generally not too large, mostly light and medium intensity, long duration, rhythmic exercise, such as walking, jogging, cycling, swimming, playing tai chi, etc.. Aerobic exercise, oxygen can fully burn (i.e., oxidation) body sugar, but also consume body fat to maintain a suitable body weight, enhance and improve cardiorespiratory function, enhance endurance quality, prevent osteoporosis, and regulate the psychological and mental state, is the main form of fitness exercise. The U.S. National Institutes of Health (NIH) recommends no less than 150 minutes of exercise per week and no less than three times a week of moderate intensity aerobic exercise. Anaerobic exercise: Also known as resistance exercise. Characterized by relatively high intensity, instantaneous, very low oxygen uptake during exercise, muscle almost hypoxia, often feel muscle soreness after exercise due to lactic acid buildup, and different exercise can mobilize different parts of the muscle activity, there is a certain amount of regional. Resistance exercise can increase muscle strength and muscle dimension and is beneficial to the skeletal system, developing a physique that does not easily gain weight. Common forms of exercise are sprinting, weight lifting, push-ups, muscle training, etc. Stretching: Also known as preparation or relaxation exercises. It is a slow, soft, rhythmic movement that increases muscle flexibility and body coordination, promotes blood circulation, and prevents muscle and joint injuries, usually before and after exercise. Stretching can minimize sports injuries while promoting the excretion of accumulated lactic acid and relieving muscle soreness, as well as stretching the outer membrane of the muscle and promoting increased muscle dimension. More studies have found that regular physical exercise can improve and enhance the metabolic activities and working ability of various body systems and organs of the elderly, such as the heart, lungs, bones, immune and nervous systems, enhance body resistance, prevent common diseases of the elderly, thus reducing and delaying the physiological aging process, while promoting sleep, restoring and maintaining mental health, postponing psychological aging, and extending both physiological and psychological aspects of life expectancy. However, some studies have found that strenuous or super-intense exercise can accelerate aging. Strenuous exercise, often beyond the human physiological tolerance, disrupt the balance of the internal and external environment of the human body, accelerate the wear and tear of certain organs in the body and physiological dysfunction, inhibit the function of the immune system, thus weakening the body’s resistance to weaken, easy to contract diseases, shorten the life process and accelerate aging.