If there is no change after 10 days of anti-infective treatment for multiple nodules in both lungs, it is considered that the antibiotic is not appropriate or tuberculosis, and antibiotic or anti-tuberculosis treatment can be changed, and anti-tumor treatment can be carried out for tumor. 1. If the examination found multiple nodules in both lungs, but after 10 days of anti-infective treatment has no effect, the first consideration is that the choice of antibiotics is not appropriate or there is a history of drug resistance, we need to carry out sputum culture as well as drug sensitivity test in a timely manner, and according to the results of the choice of other antibiotics for treatment, such as penicillin replacement for levofloxacin, and so on. 2. Ineffective anti-infective treatment also needs to consider non-bacterial infection factors caused by lung nodules, including tuberculosis, fungi, tumors, etc., need to timely relevant examinations, such as bronchoscopy or CT-guided lung nodule tissue puncture to send pathology, according to the cause of the disease to take targeted treatment. The appearance of multiple nodules in both lungs anti-inflammatory ten days without change, need to consult a doctor in a timely manner, in accordance with the doctor’s instructions for reasonable treatment, the drugs need to be under the guidance of a physician reasonable application.