A team led by Professor Yu Xianjuan from the Department of Pancreatic Hepatobiliary Surgery, Institute of Pancreatic Oncology/Fudan University Cancer Hospital, Fudan University, discovered that the immune status of pancreatic cancer patients directly affects the long-term outcome after surgery through a simple and effective method to assess the immune status of pancreatic cancer patients by analyzing clinical data from a large sample. This research further emphasizes the important role of immune supportive therapy in cancer patients and was published in Pancreatology (2014), a professional journal of the International Pancreatic Diseases Association. Professor Xian-Jun Yu from Cancer Hospital of Fudan University is the corresponding author of this paper. Professor Yu is mainly engaged in clinical and basic translational research on pancreatic cancer, conducting research on individualized and standardized treatment centered on surgery, exploring the malignant biology of pancreatic cancer and the related immune mechanism. Pancreatic cancer is the king of cancers, and although surgery is currently the only possible curative means, there is still no significant progress in the long-term outcome after surgery. Recurrence and metastasis after surgery are still the primary problems faced after surgery, so how to determine the high-risk factors and how to predict the population with high risk of recurrence are real challenges for clinicians in clinical decision making. Professor Yu’s research team systematically analyzed a group of consecutive cases from the Institute of Pancreatic Oncology, Fudan University, with a total of 160 patients who underwent radical pancreatic cancer surgery, and prospectively examined the changes of peripheral immune cell subsets in the perioperative period. cell subpopulation dynamics in the peripheral blood of patients can predict the survival of patients in the long term. The stronger the immune status, the longer the postoperative survival; 3) This study also found an interesting phenomenon that despite the high trauma and slow recovery of radical pancreatic cancer surgery, the postoperative immune status was stronger than the preoperative status in patients who obtained radical resection, a finding that also strongly demonstrates that the removal of tumor load can reverse immunosuppression, emphasizing the important role of radical surgery. The findings of this study have important implications for clinical treatment strategies. Due to the malignant biological behavior of pancreatic cancer, the tumor manifestations can be reflected in the whole body from the beginning stage, the first and foremost of which is the immune system of the body. From the immunological point of view, the development of tumor has always been carried out through these 3 processes, the dysfunction of immunosurveillance of the body, the immunoediting of tumor cells by the immune system, and the immune escape of the tumor through various mechanisms, which eventually leads to the tumor progression. Therefore, the immune status of the body directly affects the development of tumor. This study suggests that the immune status of the body can be effectively predicted by detecting and assessing the peripheral immune cell subpopulation of patients, and then the high-risk population can be screened. Timely and effective interventions in these populations would greatly benefit patients. This study also illustrates the importance of immunomodulation of the organism and therefore the benefits of timely immunomodulatory therapy in the clinical management of tumor patients. In addition, this study further illustrates the significance of radical surgical resection of tumors, which, in addition to completely removing the tumor load, can fundamentally reverse the immunosuppressive state of the tumor, which is a strong response to the so-called bias that “surgery can be very debilitating”.