Neck and shoulder pain may not necessarily mean frozen shoulder or cervical spondylosis, especially when the neck and shoulder pain persists or gradually worsens, it is more important to seek timely medical consultation. The most common symptoms of lung cancer are respiratory symptoms such as cough, sputum, sputum and blood, etc. Although acinar lung cancer originates from the lung, its lung symptoms are less due to the uniqueness of the tumor growth location, and extra-pulmonary symptoms are relatively more. The first symptom of about 95% of patients with acinar lung cancer is limited pain in the shoulder, scapula and vertebral edges, which may radiate upward to the neck and top of the head, and downward to the medial scapula, axilla, anterior chest and medial upper arm. In frozen shoulder, the pain is relatively limited in location and can worsen when climate changes or after exertion. Neck and shoulder pain in pulmonary acromegaly is often accompanied by numbness and abnormal sensation in the upper limbs, muscle atrophy in the hands and drooping of one eyelid. Simple frozen shoulder rarely shows the above symptoms, but it is often accompanied by coldness of the affected shoulder and limitation of shoulder joint activities, mainly abduction, supination and internal and external rotation of the shoulder joint. It should be distinguished from cervical spondylosis. It is important to be vigilant, especially when neck and shoulder pain persists or gradually worsens, and to seek timely medical consultation to prevent missing the diagnosis of pulmonary acromegaly.