Many patients have a perception of non-steroidal anti-inflammatory drugs (NSAIDs) such as acitretin, celecoxib, and meloxicam: they are “painkillers”, they only relieve pain and do not help improve the disease itself, and they are “addictive” when taken for a long time. Is this really the case? In the spirit of responsible attitude to health, I have carefully compiled for you from the authoritative expert guidance on medication. 1, what is a non-steroidal anti-inflammatory drugs non-steroidal anti-inflammatory drugs is a large class of drugs, with antipyretic, analgesic, anti-inflammatory effect of non-hormonal drugs, such as aspirin, indomethacin, ibuprofen, diclofenac, etc.. The so-called inflammation often includes the four symptoms of “redness, swelling, heat and pain”, so people often call these drugs “painkillers”, but pain relief is only one of the roles of these drugs. The fundamental role of NSAIDs in the treatment of ankylosing spondylitis is to control inflammation and relieve pain through anti-inflammatory effects, rather than simple pain relief, and morphine, codeine and other narcotic painkillers that act on the nerves is completely different, long-term use and non-addictive. 2, non-steroidal anti-inflammatory drugs for ankylosing Ankylosing spondylitis is an inflammatory disease that mainly involves the spine and sacroiliac joints, inflammation is the most prominent disease feature of the ankylosing spine, and is the most fundamental cause of new bone formation and spinal ankylosis in patients with ankylosing spine. Therefore, the 2010 update of the International Spondyloarthritis Society (ASAS) and the European League Against Rheumatism (EULAR) recommendations for the treatment of AS includes NSAIDs as the first line of treatment for ankylosing spondylitis. NSAIDs should be taken regardless of whether the patient feels pain or not, as long as there is active inflammation present. 3.Cautions & FAQ ⑴How long should I use NSAIDs? During the period of active disease, if there is no adverse reaction, it is recommended to take them regularly on a daily basis. If the disease is well controlled, it is still not recommended to stop the medication immediately, but to gradually reduce the dose or lengthen the interval between doses under the guidance of rheumatologists. If there is no significant improvement of symptoms after 2-4 weeks of treatment with a certain NSAID, it should be changed to other kinds of anti-inflammatory drugs. (2) Is it possible to combine NSAIDs? It is not recommended to use 2 or more NSAIDs at the same time, and the simultaneous use of multiple NSAIDs increases the adverse reactions and does more harm than good in the long term. (3) Pay attention to the monitoring of adverse reactions: the most common adverse reactions to the use of such drugs are gastrointestinal discomfort (including poor appetite, anorexia, abdominal pain, etc.), followed by abnormal liver and kidney function. Blood and urine routine, liver and kidney function should be checked regularly before and after treatment, and if there is obvious gastrointestinal discomfort or darkening of stool, hospital should be checked in time.