Urine yellow urine odor may be due to urinary tract infection or physiological factors, according to different situations apply anti-infective drugs for treatment or increase drinking water, timely urination to improve. Most of the yellow urine odor is due to urinary tract infection, different urinary tract infection application of different drugs, if it is caused by bacteria, etc., need to apply cephalosporin, penicillin, quinolone antibiotics, more commonly used amoxicillin, cefixime, levofloxacin and so on. A small number of patients are due to mycoplasma, chlamydia infection, need to apply doxycycline, azithromycin and so on. Few patients are due to mold, need to apply the appropriate anti-mold drugs, such as fluconazole, amphotericin and so on. If patients drink too little water or urinate for a long time after the storage can also lead to yellow urine odor, this is not caused by the disease, only need to drink more water, no need to take medication. Patients with yellow urine odor, need to complete the urine routine, if necessary, urine culture, according to the causative organisms of different selection of the corresponding drug treatment. All kinds of drugs have side effects, need to follow the doctor’s advice to take, not self-medication.