Stubborn constipation can be improved by medicines under doctor’s guidance, such as laxatives, stimulants and enemas. 1. Laxatives: for example, stimulating laxatives can enhance intestinal motility and stimulate intestinal secretion, such as sarcosine; volumetric laxatives can increase the water content of feces, thereby increasing the volume of feces to play the role of laxative, such as polycarbophilic calcium, etc.; osmotic laxatives can absorb water, forming a hypertonic state in the intestine, increasing the volume of feces and can stimulate intestinal peristalsis, such as polyethylene glycol, lactulose and so on. 2. Pro-dynamic drugs: can regulate neurotransmitters or directly act on smooth muscle to increase intestinal power, such as mosapride, prucalopride, etc.. 3. Enema: can lubricate and stimulate the intestinal wall, soften the feces, so that it is easy to discharge, such as Keseru and so on. It is recommended that patients with persistent constipation consult a doctor in time and standardize the treatment under the guidance of the doctor.