Cerebral edema coma for 16 days, whether to continue the treatment needs to be based on the patient’s cause of cerebral edema, physical condition, family financial situation and other factors. 1. Causes of cerebral edema: If cerebral edema coma is caused by diffuse axonal damage due to trauma, it is unlikely to wake up and may easily lead to vegetative state, so the treatment is of little significance; if cerebral hemorrhage leads to cerebral edema coma, with the gradual subsiding of the cerebral edema, the consciousness can be restored, although it may lead to disability, but there is still a need for treatment. 2. Physical condition: if the patient’s condition is poor, combined with cardiac and pulmonary insufficiency, and the vital signs are not stable, the treatment is of little significance; if the patient’s condition is good, it is generally recommended to continue the treatment. 3. Family economic situation: patients in coma with cerebral edema are in serious condition, and the treatment cost is high, which puts a greater burden on family economy, so those with poor economic situation may not be able to continue to maintain the treatment. Whether or not to continue treatment after 16 days of coma with cerebral edema needs to be determined by a combination of factors, and it is recommended to follow the advice of a medical professional.