The difference between orchitis and varicocele lies in the different causes, symptoms and treatments. 1. Causes: Testicular inflammation is mostly caused by viruses and bacteria; while varicocele is mostly caused by congenital factors, such as congenital dysplasia of vein wall. 2. Symptoms: Testicular inflammation is characterized by testicular enlargement and pain, which may radiate to the scrotum; varicocele is usually asymptomatic, but in serious cases, it may result in the enlargement of the scrotum on the affected side, hidden pain, and aggravation after standing for a long time. 3. Treatment: The treatment of testicular inflammation is mostly antibiotic treatment, such as levofloxacin, etc.; varicocele can be treated with physical therapy, such as hypothermia, medication, such as indomethacin, etc., as well as surgical treatment. In case of testicular inflammation and varicocele, clinicians should be consulted and medical advice should be followed for rational treatment.