With the rapid development of fat aspiration technology, fat reuse has also become a popular trend. With the popularization of the concept of “Coleman technique”, the autologous fat transplantation technology has gradually matured. Through minimally invasive fat extraction, moderate centrifugation and multi-point, multi-planar, multi-level and micro-transplantation methods, fat transplantation has achieved a higher survival rate and good results in the face and breast. It not only plays the role of volume filling, but also has anti-aging effects such as improving skin texture, promoting tissue healing and improving wrinkles due to the presence of fat-derived mesenchymal stem cells. Autologous fat grafting has become a safe, long-lasting and more versatile form of minimally invasive anti-aging surgery. Facial fat is composed of multiple groups of fat masses, and the facial contours of young people are in harmony with the distribution of fat, with each group of fat masses shrinking and changing position to varying degrees during the aging process. Although we still do not know the cause of facial aging, the structural balance of the face can be restored by transplanting autologous fat to atrophied areas, thus restoring a youthful appearance. Common complications include infection, overcorrection, asymmetry, sclerosis, bruising at the injection site, depressions, and fat cysts. Rare complications include infarction of the middle cerebral artery, skin necrosis and blindness. However, with the blunt needle microinjection technique we now use, vascular embolism is rare because of the low probability of needle insertion into a blood vessel and the low pressure of the 1 ml syringe. Still, because of the seriousness of the complications, extra care should be taken to prevent the occurrence of vascular embolism in every way possible. Autologous fat has always been a safe, economical, sure and long-lasting minimally invasive anti-aging modality, and is a more ideal choice for patients with aging facial volume loss. Proper understanding of the changes in fat volume in various parts of the aging face and proper application of fat acquisition methods and filling techniques are the keys to successful treatment.