AST is glutathione aminotransferase, a liver function that reflects the overall condition of the patient’s liver function and the presence of hepatocellular necrosis. In such cases, if there is an elevation of glutathione and glutamic oxalacetic aminotransferase, it is important to consider whether the patient has liver insufficiency or hepatocellular necrosis due to underlying liver disease. If necessary, the patient needs to be further examined to identify whether the impairment is transient or due to underlying liver disease. If the former is the case, the patient should be considered to be suffering from alcohol, medication, fatigue or emotional problems. For some patients with high aminotransferases, oral bupropion drops or dicyclomine tablets can be considered to lower aminotransferases. If the patient has underlying liver disease, such as hepatitis or other cirrhosis, the patient needs to be treated for the cause of the disease. Patients with viral hepatitis who have viral replication need antiviral therapy if necessary, and then consider liver-protective therapy.