Every fall, the incidence of asthma rises significantly. However, why is the incidence of asthma so high in the fall when there is neither the stimulation of winter cold nor the triggering of large amounts of pollen and other allergens in the spring? Can we reduce asthma attacks by wearing more clothes to prevent getting cold? Or can we avoid asthma attacks caused by allergens or bad stimuli by going to parks or public places less often? However, it is frustrating that even with these precautions, asthma often comes back in the fall. So, what is the origin of autumn and the development of asthma? How can we really reduce or control asthma attacks in the fall. To clarify these issues, we must first understand the pathogenesis of asthma. It is often said that people live on a breath of air, through which our body gets the nutrients it needs – oxygen. However, the tube that carries oxygen, which we call the trachea, has become diseased in some bodies, causing difficulties in the entry and exit of gases, which is called bronchial asthma, or asthma for short. As medical science has evolved, so has our understanding of asthma. From the beginning, asthma attacks were thought to be caused by airway spasms, contractions, and reversible narrowing of the tracheal lumen, resulting in poor ventilation and even respiratory distress; to the discovery that asthma is a chronic inflammatory disease of the airways, with progressive, irreversible narrowing of the lumen and hyperresponsiveness of the airways due to the inflammation. As a result, we know that asthma is a chronic disease with a serious and progressive development that, if left unchecked, will eventually lead to irreversible and serious consequences. The airways of asthma patients are hyperreactive due to the destruction of the surface mucosa, the exposure of nerve endings, and the thickening of the smooth muscle of the walls, which is like a highly sensitive “thermometer” that is sensitive to the temperature of the outside air entering the airways. The change in temperature will cause a strong stimulation of the airway, causing airway contraction and triggering asthma. Since the temperature changes a lot in autumn, and we have to breathe when we are alive, we have to inhale the air with changing temperature every moment, and we cannot reduce the stimulation of airway by wearing more clothes to keep warm, therefore, the onset of asthma seems inevitable in autumn. Some glandular cells in the mucous membrane of the airway surface can secrete certain mucus, which plays a protective role for the airway surface. The fall in air humidity and dry climate make the mucus on the airway surface volatilize, making the lesions where inflammation occurs in asthma patients directly exposed to air with significant temperature differences, resulting in a particularly sensitive response of the airways to adverse stimuli such as temperature differences. There seems to be nothing we can do about this. In autumn, due to the large change in climate temperature between day and night, if we do not pay attention to add clothes, we are susceptible to cold and cause respiratory infections. Among the respiratory infections, most of them are mainly viral infections, and respiratory viral infections are closely related to the development of asthma. Autumn is also an important reason for the increase of asthma attacks due to more respiratory infections. In autumn, many more delicious dishes are added to the diet. Among them, a large amount of river food and seafood are common allergens that cause some asthma attacks. In addition, with the change of seasons, the living environment, clothing and other aspects of the autumn has also undergone some changes. As the climate becomes cooler in autumn, clothing will also increase accordingly. Some cotton fabrics and chemical fiber clothes not used in summer, including indoor products such as bedspreads, bed sheets, quilt covers, pillow cases, pillow cases, cotton quilt tires and mattresses, may cause asthma attacks in some patients. Therefore, the onset of asthma in autumn seems to come and go without a trace, which is unpreventable. However, with the development of medical science and in-depth research on asthma, asthma is no longer an elusive disease, and the prevention and treatment of asthma is no longer helpless, as long as systematic and standardized treatment, asthma can be well controlled, and asthma patients can also live, work and study without any worries as normal people.