Wheezing is a common clinical manifestation in infants and toddlers under 3 years of age, but the question of whether asthma is present or what the chances are of developing asthma in the future has always been a troubling one for parents and even pediatricians. Studies have shown that wheezing is a common clinical manifestation in infants and toddlers under 3 years of age, but the question of whether asthma is present or what the chances are of developing asthma in the future has been a troubling one for parents and even pediatricians. Studies have shown that using the Asthma Predictive Index, pediatricians can make a preliminary determination. A positive Asthma Predictor Index is defined as having one major risk factor or two minor risk factors. The primary risk factors are: 1) family history of asthma in the parents, 2) physician-diagnosed atopic dermatitis (eczema, etc.), and 3) positive test for inhalant allergens. Secondary risk factors are: 1) evidence of food allergen sensitization, 2) peripheral blood eosinophil R4%, 3) wheezing unrelated to a cold. Prediction: In children under 3 years of age with R4 wheezing episodes in a year, the risk of developing asthma at 6-13 years of age is 4-6 times higher if the asthma prediction index is positive; if the API is negative, 95% do not develop asthma. Therefore, for high-risk infants and children with a positive asthma predictive index, we recommend standardized treatment for asthma.